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61.
Recent reports have shown that the molecular mechanisms involved in root stem-cell niche development in Arabidopsis thaliana are complex and contain several feedback loops and non-additive interactions that need to be analyzed using computational and formal approaches. Complex systems cannot be understood in terms of the behavior of their isolated components, but they emerge as a consequence of largely non-linear interactions among their components. The study of complex systems has provided a useful approach for the exploration of system-level characteristics and behaviors of the molecular networks involved in cell differentiation and morphogenesis during development. We analyzed the complex molecular networks underlying stem-cell niche patterning in the A. thaliana root in terms of some of the key dynamic traits of complex systems: self-organization, modularity and structural properties. We use these analyses to integrate the available root stem-cell niche molecular mechanisms data and postulate novel hypotheses, missing components and interactions and explain apparent contradictions in the literature. 相似文献
62.
Caballero L Benítez M Alvarez-Buylla ER Hernández S Arzola AV Cocho G 《Journal of experimental zoology. Part B, Molecular and developmental evolution》2012,318(3):209-223
Pigment patterning in animals generally occurs during early developmental stages and has ecological, physiological, ethological, and evolutionary significance. Despite the relative simplicity of color patterns, their emergence depends upon multilevel complex processes. Thus, theoretical models have become necessary tools to further understand how such patterns emerge. Recent studies have reevaluated the importance of epigenetic, as well as genetic factors in developmental pattern formation. Yet epigenetic phenomena, specially those related to physical constraints that might be involved in the emergence of color patterns, have not been fully studied. In this article, we propose a model of color patterning in which epigenetic aspects such as cell migration, cell-tissue interactions, and physical and mechanical phenomena are central. This model considers that motile cells embedded in a fibrous, viscoelastic matrix-mesenchyme-can deform it in such a way that tension tracks are formed. We postulate that these tracks act, in turn, as guides for subsequent cell migration and establishment, generating long-range phenomenological interactions. We aim to describe some general aspects of this developmental phenomenon with a rather simple mathematical model. Then we discuss our model in the context of available experimental and morphological evidence for reptiles, amphibians, and fishes, and compare it with other patterning models. We also put forward novel testable predictions derived from our model, regarding, for instance, the localization of the postulated tension tracks, and we propose new experiments. Finally, we discuss how the proposed mechanism could constitute a dynamic patterning module accounting for pattern formation in many animal lineages. 相似文献
63.
SANTIAGO F. ELENA FRANCISCO M. CODOÑER RAFAEL SANJUÁN 《Biological journal of the Linnean Society. Linnean Society of London》2003,79(1):17-26
This paper explores the evolutionary implications of the enormous variability that characterizes populations of RNA viruses and retroviruses. It begins by examining the magnitude of genetic variation in both natural and experimental populations. In natural populations, differences arise even within individual infected patients, with the per-site nucleotide diversity at this level ranging from < 1% to 6%. In laboratory populations, two viruses sampled from the same clone differed by ∼0.7% in their fitness. Three different mechanisms that may be important in maintaining viral genetic variability were tested: (1) Fisher's fundamental theorem, to compare the observed rate of fitness change with the extent of fitness-related variation within the same experimental populations; (2) magnitude of genomic mutation rate, to assess whether it correlated with fitness-related variation, as predicted by the mutation-selection balance hypothesis; (3) frequency-dependent selection, which affords rare genotypes an advantage. The paper concludes with a discussion of two evolutionary consequences of variability: the fixation of deleterious mutations by drift in small populations and the role of clonal interference in large ones. © 2003 The Linnean Society of London. Biological Journal of the Linnean Society , 2003, 79 , 17–26. 相似文献
64.
J. K. ERÄNEN J. NILSEN V. E. ZVEREV M. V. KOZLOV 《Journal of evolutionary biology》2009,22(4):840-851
Stress adaptations often include a trade‐off of weakened performance in nonlocal conditions, resulting in divergent selection, and potentially, genetic differentiation and evolutionary adaptation. Results of a two‐phase (greenhouse and field) common garden experiment demonstrated adaptation of mountain birch (Betula pubescens subsp. czerepanovii) populations from industrially polluted areas of the Kola Peninsula, north‐western Russia, to heavy metals (HM), whereas no adaptations to wind or drought stress were detected in populations from wind‐exposed sites. HM‐adapted seedlings were maladapted to drought but less palatable (co‐resistant) to insect herbivores, even under background HM concentrations. The absence of adaptations to harsh microclimate and the generally high adaptive potential of mountain birch, a critical forest forming tree in subarctic Europe, need to be accounted for in models predicting consequences of human‐driven environmental changes, including the projected climate change. 相似文献
65.
Sherif M Amr Ahmad M Essam Amr MS Abdel-Meguid Ahmad M Kholeif Ashraf N Moharram Rashed ER El-Sadek 《Journal of brachial plexus and peripheral nerve injury》2009,4(1):1-17
Background
The superiority of a single stage combined anterior (first) posterior (second) approach and end-to-side side-to-side grafting neurorrhaphy in direct cord implantation was investigated as to providing adequate exposure to both the cervical cord and the brachial plexus, as to causing less tissue damage and as to being more extensible than current surgical approaches.Methods
The front and back of the neck, the front and back of the chest up to the midline and the whole affected upper limb were sterilized while the patient was in the lateral position; the patient was next turned into the supine position, the plexus explored anteriorly and the grafts were placed; the patient was then turned again into the lateral position, and a posterior cervical laminectomy was done. The grafts were retrieved posteriorly and side grafted to the anterior cord. Using this approach, 5 patients suffering from complete traumatic brachial plexus palsy, 4 adults and 1 obstetric case were operated upon and followed up for 2 years. 2 were C5,6 ruptures and C7,8T1 avulsions. 3 were C5,6,7,8T1 avulsions. C5,6 ruptures were grafted and all avulsions were cord implanted.Results
Surgery in complete avulsions led to Grade 4 improvement in shoulder abduction/flexion and elbow flexion. Cocontractions occurred between the lateral deltoid and biceps on active shoulder abduction. No cocontractions occurred after surgery in C5,6 ruptures and C7,8T1 avulsions, muscle power improvement extended into the forearm and hand; pain disappeared.Limitations include
spontaneous recovery despite MRI appearance of avulsions, fallacies in determining intraoperative avulsions (wrong diagnosis, wrong level); small sample size; no controls rule out superiority of this technique versus other direct cord reimplantation techniques or other neurotization procedures; intra- and interobserver variability in testing muscle power and cocontractions.Conclusion
Through providing proper exposure to the brachial plexus and to the cervical cord, the single stage combined anterior (first) and posterior (second) approach might stimulate brachial plexus surgeons to go more for direct cord implantation. In this study, it allowed for placing side grafts along an extensive donor recipient area by end-to-side, side-to-side grafting neurorrhaphy and thus improved results.Level of evidence
Level IV, prospective case series. 相似文献66.
67.
An AGAMOUS-related MADS-box gene, XAL1 (AGL12), regulates root meristem cell proliferation and flowering transition in Arabidopsis 总被引:3,自引:0,他引:3
68.
Cells in the astroglial lineage are neural stem cells 总被引:1,自引:0,他引:1
A common assumption of classical neuroscience was that neurons and glial cells were derived from separate pools of progenitor
cells and that, once development was completed, no new neurons were produced. The subsequent disproving of the “no new neuron”
dogma suggested that ongoing adult neurogenesis was supported by a population of multipotent neural stem cells. Two germinal
regions within the adult mammalian brain were shown to contain neural progenitor cells: the subventricular zone (SVZ) along
the walls of the lateral ventricles, and the subgranular zone (SGZ) within the dentate gyrus of the hippocampus. Surprisingly,
when the primary progenitors (stem cells) of the new neurons in these regions were identified, they exhibited structural and
biological markers of astrocytes. The architecture of these germinal regions and the pattern of division of neural stem cells
have raised fundamental questions about the mechanism of adult neurogenesis. This review describes studies on the origin of
adult neural stem cells, the features distinguishing them from astrocytes in non-germinal regions, and the control mechanisms
of the proliferation and differentiation of these cells. Astrocytic adult neural stem cells are part of a developmental lineage
extending from the neuroepithelium to radial glia to germinal astrocytes. Adult neural stem cells appear to be strongly influenced
by their local microenvironment, while also contributing significantly to the architecture of these germinal zones. However,
environment alone does not seem to be sufficient to induce non-germinal astrocytes to behave as neural stem cells. Although
emerging evidence suggests that significant heterogeneity exists within populations of germinal zone astrocytes, the way that
these differences are encoded remains unclear. The further characterization of these cells should eventually provide a body
of knowledge central to the understanding of brain development and disease.
Work in the Alvarez-Buylla laboratory is supported by grants from the NIH and the Goldhirsh Foundation and by a gift from
John and Frances Bowes. Rebecca Ihrie is a Damon Runyon Fellow supported by the Damon Runyon Cancer Research Foundation. Arturo
Alvarez-Buylla holds the Heather and Melanie Muss Endowed Chair in Neurosurgery. 相似文献
69.
Guillermo A. Cecchi Leopoldo T. Petreanu Arturo Alvarez-Buylla Marcelo O. Magnasco 《Journal of computational neuroscience》2001,11(2):175-182
Adult neurogenesis has long been documented in the vertebrate brain and recently even in humans. Although it has been conjectured for many years that its functional role is related to the renewing of memories, no clear mechanism as to how this can be achieved has been proposed. Using the mammalian olfactory bulb as a paradigm, we present a scheme in which incorporation of new neurons proceeds at a constant rate, while their survival is activity-dependent and thus contingent on new neurons establishing suitable connections. We show that a simple mathematical model following these rules organizes its activity so as to maximize the difference between its responses and can adapt to changing environmental conditions in unsupervised fashion, in agreement with current neurophysiological data. 相似文献
70.